Assistant Professor
Department of Biomedical Chemistry, College of Biomedical and Health Science, Konkuk University, GLOCAL Campus.
Phone: 010-6331-8223, Email: jhlim@kku.ac.kr
Education and Training
· Post-doc: Department of Cell Biology, Dana-Farber Cancer Institute, Harvard Medical School, USA
· Ph.D. in Pharmacology: College of Medicine, Seoul National University, Korea
· M.S. in Molecular Genetics: College of Medicine, Seoul National University, Korea
· B.S. in Biochemistry: Konkuk University GLOCAL campus, Korea
Research Interest
1. Identification and development of molecular targets for cancer therapy
2. Understanding transcriptional mechanism on metabolic reprogramming in cancer
3. Identification of novel chromatin complexes and understanding their mechanistic role on metabolic homeostasis in peripheral tissues as well as malignant tumor
Selected 5 publication
Statins Decrease Programmed Death-Ligand 1 (PD-L1) by Inhibiting AKT and β-Catenin Signaling. Lim WJ, Lee M, Oh Y, Fang XQ, Lee S, Lim CH, Park J, Lim JH. Cells. 2021 Sep 20;10(9):2488. doi: 10.3390/cells10092488.
PGC1α Loss Promotes Lung Cancer Metastasis through Epithelial-Mesenchymal Transition. Oh TI, Lee M, Lee YM, Kim GH, Lee D, You JS, Kim SH, Choi M, Jang H, Park YM, Shin HW, Shin DH, Lim JH. Cancers (Basel). 2021 Apr 8;13(8):1772. doi: 10.3390/cancers13081772.
HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways. Kang H, Oh T, Bahk YY, Kim GH, Kan SY, Shin DH, Kim JH, Lim JH. Cancers (Basel). 2019 Sep 13;11(9):1363. doi: 10.3390/cancers11091363.
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis. Luo C*, Lim JH*, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P. Nature. 2016 Sep 15;537(7620):422-426. doi: 10.1038/nature19347. Epub 2016 Aug 31. * equal contribution
Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation. Lee G, Won HS, Lee YM, Choi JW, Oh TI, Jang JH, Choi DK, Lim BO, Kim YJ, Park JW, Puigserver P, Lim JH. Sci Rep. 2016 Jan 7;6:18928. doi: 10.1038/srep18928.
