Professor
Lab. of Structural Biology and Protein Engineering, Department of Biotechnology, College of Biomedical and Health Science, Konkuk University GLOCAL Campus (2005 ~ present)
Phone: +82-43-8403589, Email: wonhs@kku.ac.kr
Education and Training
· Post-doctoral research associate: Depart. of Mol. Biol., The Scripps Research Institute, CA, USA
· Ph.D. in Physical Pharmacy: College of Pharmacy, Seoul National University, Korea
· M.S. in Physical Pharmacy: College of Pharmacy, Seoul National University, Korea
· B.S. in Manufacturing Pharmacy: College of Pharmacy, Seoul National University, Korea
Research Interest
· Structure-function relationships of proteins: transcription factors, molecular chaperones, and disease-related proteins
· Structure-based drug discovery: protein-protein interaction inhibitors and protein folding regulators
· Development and characterization of biopharmaceutical agents: therapeutic/diagnostic antibody and bioactive peptide engineering
Selected publications
· Rational discovery of anti-metastatic agents targeting the intrinsically disordered region of MBD2, Sci. Adv. 5, eaav9810 (2019)
· Structural changes of antitoxin HigA from Shigella flexneri by binding of its cognate toxin HigB, Int. J. Biol. Macromol. 130, 99-108 (2019)
· Unique unfoldase/aggregase activity of a molecular chaperone Hsp33 in its holding-inactive state, J. Mol. Biol. 431, 1468-1480 (2019)
· Enhancing bacterial production of a recombinant cetuximab-Fab by a partial humanization and its utility for drug conjugation, Process Biochem. 69, 123-130 (2018)
· C-terminal dimerization of apo-cyclic AMP receptor protein validated in solution, FEBS Lett. 591, 1064-1070 (2017)
· Structural identification of the lipopolysaccharide-binding capability of a cupin-family protein from Helicobacter pylori, FEBS Lett. 590, 2997-3004 (2016)
· Anti-inflammatory action of an antimicrobial model peptide that suppresses the TRIF-dependent signaling pathway via inhibition of toll-like receptor 4 endocytosis in lipopolysaccharide-stimulated macrophages, PLoS One 10, e0126871 (2015)
